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d-serine-symptoms-of-schizophrenia

High Dose D-serine In The Treatment Of Schizophrenia

効果 減少
試験方法 コホート法
試験期間 2-4 週間
被験者数 42
性別 男女
この研究の注釈:

D-Serine at doses between 30-120mg/kg was dose-dependently effective in reducing all symptoms of schizophrenia, with 30mg/kg being ineffective on some (but not all) parameters. Improvements in symptoms appeared to correlate with blood D-serine concentrations


A Randomized, Double-blind, Placebo-controlled Comparison Study Of Sarcosine (N-methylglycine) And D-serine Add-on Treatment For Schizophrenia
効果 なし
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 60
性別 男女
年齢 30-44, 45-64
この研究の注釈:

In 60 persons with schizophrenia given 2,000mg D-serine daily for 6 weeks, D-serine supplementation failed to outperform placebo on all measured parameters while the reference drug (sarcosine) was effective at the same dose.


D-serine Added To Antipsychotics For The Treatment Of Schizophrenia
効果 減少
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 28
性別 男女
年齢 18-29, 30-44, 45-64
この研究の注釈:

Supplementation of 30mg/kg D-serine to schizophrenic patients for 6 weeks was able to reduce all symptoms of schizophrenia, and serum concentrations of D-serine were able to predict the improvements seen in rating scales.


D-serine Efficacy As Add-on Pharmacotherapy To Risperidone And Olanzapine For Treatment-refractory Schizophrenia
効果 減少
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 39
性別 男女
年齢 30-44, 45-64
この研究の注釈:

30mg/kg of D-serine daily in addition to antipsychotic therapy (risperidone or olanzapine) was able to improve negative, positive, depressive, and cognitive scores over 6 weeks with the improvement on symptoms being 4.3-20.6% (95% CI of SAS rating scale), 19.8-57.7% (95% CI of AIMS), and 14 patients on D-serine noted over a 20% improvement on negative and positive symptoms while only 2 subjects on placebo did.


Sarcosine Or D-serine Add-on Treatment For Acute Exacerbation Of Schizophrenia: A Randomized, Double-blind, Placebo-controlled Study
効果 なし
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 65
性別 男女
年齢 30-44, 45-64
この研究の注釈:

6 weeks supplementation of 2,000mg D-serine (compared to both placebo and an equal dose of sarcosine) has failed to outperform placebo when both were added to risperidone therapy.


A Multicenter, Add-on Randomized Controlled Trial Of Low-dose D-serine For Negative And Cognitive Symptoms Of Schizophrenia
効果 なし
試験方法 二重盲検法
試験期間 6+ ヶ月
被験者数 195
性別 男女
年齢 18-29, 30-44, 45-64
この研究の注釈:
スポンサーリンク

In 195 persons with schizophrenia already on antipsychotic treatment, the addition of 2,000mg D-serine daily for 16 weeks failed to outperform placebo at controlling positive and negative symptoms of schizophrenia and failed to significantly affect cognition.


管理人 :慶應義塾大学の理工学部卒業後、国内外でコンサルティング業務やスタートアップの立ち上げを経験した後、日本に帰国してから健康・医療の情報を収集して発信しています。 趣味:ネットサーフィン、読書(最近かなり減ってますが)、アウトドア(家族と) 毎日メディテーションとジョギング、筋トレ・ストレッチしています。既婚で子供4人(男女女男)です。