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dehydroepiandrosterone-serum-dhea

Androgens And Sexual Function: A Placebo-controlled, Randomized, Double-blind Study Of Testosterone Vs. Dehydroepiandrosterone In Men With Sexual Dysfunction And Androgen Deficiency

効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 79
性別 男性
年齢 45-64, 65+
体型 肥満
この研究の注釈:

DHEA, at 100mg daily in older (average age of 60) men with sexual dysfunction over 16 weeks failed to significantly increase testosterone (despite increasing DHEA and DHEAS) and subsequently failed to improve the state of sexual dysfunction the participants were in.


Effect Of Acute DHEA Administration On Free Testosterone In Middle-aged And Young Men Following High-intensity Interval Training
効果 増加
試験方法 二重盲検法
試験期間 24 hours
被験者数 16
性別 男性
年齢 18-29, 45-64
体型 平均
この研究の注釈:

Acute supplementation of 50mg DHEA prior to exercise is able to promote levels of free testosterone independent of changes in testosterone in middle aged men and prevent a decline of free testosterone during exercise.


Effect Of Oral DHEA On Serum Testosterone And Adaptations To Resistance Training In Young Men
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 19
性別 男性
年齢 18-29
体型 トレーニングしてない, 平均
この研究の注釈:

DHEA supplementation at 50mg did not influence testosterone levels acutely (despite an increase in androstenedione) and 150mg of DHEA was unable to influence testosterone levels over 6 weeks in young healthy men.

No significant differences were seen in placebo versus DHEA at 150mg in regards to strength gain and lean mass accrual.


Effects Of Dehydroepiandrosterone Supplementation On Cognitive Function And Activities Of Daily Living In Older Women With Mild To Moderate Cognitive Impairment
効果 増加
試験方法 二重盲検法
試験期間 6+ ヶ月
被験者数 27
性別 女性
年齢 65+
体型 平均
この研究の注釈:

27 older frail women given DHEA over 6 months improved at cognitive parameters such as verbal fluency while the control group deteriorated.


Long-term Low-dose Dehydroepiandrosterone Oral Supplementation In Early And Late Postmenopausal Women Modulates Endocrine Parameters And Synthesis Of Neuroactive Steroids
効果 増加
試験方法 コホート法
試験期間 6+ ヶ月
被験者数 20
性別 女性
年齢 45-64
体型 肥満
この研究の注釈:

25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.


Effects Of Dehydroepiandrosterone Vs Androstenedione Supplementation In Men
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 40
性別 男性
年齢 30-44
体型 トレーニング中, 平均
この研究の注釈:

100mg of DHEA for 12 weeks in previously weight trained middle aged men was unable to increase lean mass more than placebo, but was not associated with any adverse biochemicular effects.


Dehydroepiandrosterone Combined With Exercise Improves Muscle Strength And Physical Function In Frail Older Women
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 99
性別 女性
年齢 65+
体型 肥満
この研究の注釈:

50mg of DHEA given daily for 6 months to older frail women*was unable to significantly affect bone mineral density over 6 months yet increased serum steroid status (testosterone, estrogen, DHEA) and increased lower body strength and functionality when DHEA was used in conjunction with non-strenuous exercises.


Long-term Low-dose Oral Administration Of Dehydroepiandrosterone Modulates Adrenal Response To Adrenocorticotropic Hormone In Early And Late Postmenopausal Women
効果 増加
試験方法 二重盲検法
試験期間 6+ ヶ月
被験者数 20
性別 女性
年齢 45-64
体型 肥満, 平均
この研究の注釈:

Circulating steroids increased after low dose (25mg) DHEA administration for up to a year, yet after 3 months of supplementation cortisol appeared to decline and the adrenal glands released less cortiol in response to ACTH hormone stimulation; suggesting a modification of the stress response. 17-hydroxyprogresterone only increased during months 6-12, not month 3.

Subjects were otherwise healthy menopausal women aged 50-65/


Six-month Oral Dehydroepiandrosterone Supplementation In Early And Late Postmenopause
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 36
性別 女性
年齢 45-64
体型 肥満, 平均
この研究の注釈:

50mg of DHEA over 6 months in menopausal women showed that testosterone and estrogen increased, while SHBG decreased only in overweight women significantly. Plasma levels of neurosteroids (beta-endorphin and allopregnanolone) increased while cortisol and gonadotropins decreased.

SHBG decreased only in the subset of postmenopausal women who were older and overweight.


Dehydroepiandrosterone Replacement In Healthy Men With Age-related Decline Of DHEA-S: Effects On Fat Distribution, Insulin Sensitivity And Lipid Metabolism
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 12
性別 男性
年齢 45-64
体型 肥満
この研究の注釈:

50mg of DHEA given for 3 months in a double blind manner to aged men with low circulating DHEA levels but otherwise healthy status was unable to significantly influence any study parameter despite increasing circulating DHEA levels. The only effect that was notable was an increasing trend to increase LDL and Triglycerides, which did not reach statistical significance.


Effects Of Dehydroepiandrosterone And Atamestane Supplementation On Frailty In Elderly Men
効果 増加
試験方法 二重盲検法
試験期間 6+ ヶ月
被験者数 83
性別 男性
年齢 65+
体型 肥満
この研究の注釈:

DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)


Supplementation With DHEA: Effect On Muscle Size, Strength, Quality Of Life, And Lipids
効果 増加
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 50
性別 女性
年齢 45-64, 65+
この研究の注釈:

DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.


Effects Of Dehydroepiandrosterone (DHEA) Supplementation On Hormonal, Metabolic And Behavioral Status In Patients With Hypoadrenalism
効果 増加
試験方法 コホート法
試験期間 1-6 ヶ月
被験者数 20
性別 男女
年齢 30-44, 45-64
体型 肥満
この研究の注釈:

DHEA at 50mg for 4 months was unable to influence serum testosterone levels in men, while it increased testosterone levels only in women with low circulating androgens. SHBG dropped in men and women, and DHEA-S in serum increased in both groups.
スポンサーリンク

No effects on carbohydate metabolism or insulin sensitivity were seen. Fat mass decreased, no effects on well being and quality of life were seen.

Patients were hypoadrenics.


管理人 :慶應義塾大学の理工学部卒業後、国内外でコンサルティング業務やスタートアップの立ち上げを経験した後、日本に帰国してから健康・医療の情報を収集して発信しています。 趣味:ネットサーフィン、読書(最近かなり減ってますが)、アウトドア(家族と) 毎日メディテーションとジョギング、筋トレ・ストレッチしています。既婚で子供4人(男女女男)です。