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dehydroepiandrosterone-sex-hormone-binding-globulin

Long-term Low-dose Dehydroepiandrosterone Oral Supplementation In Early And Late Postmenopausal Women Modulates Endocrine Parameters And Synthesis Of Neuroactive Steroids

効果 減少
試験方法 コホート法
試験期間 6+ ヶ月
被験者数 20
性別 女性
年齢 45-64
体型 肥満
この研究の注釈:

25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.


Dehydroepiandrosterone Combined With Exercise Improves Muscle Strength And Physical Function In Frail Older Women
効果 減少
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 99
性別 女性
年齢 65+
体型 肥満
この研究の注釈:

50mg of DHEA given daily for 6 months to older frail women*was unable to significantly affect bone mineral density over 6 months yet increased serum steroid status (testosterone, estrogen, DHEA) and increased lower body strength and functionality when DHEA was used in conjunction with non-strenuous exercises.


Six-month Oral Dehydroepiandrosterone Supplementation In Early And Late Postmenopause
効果 減少
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 36
性別 女性
年齢 45-64
体型 肥満, 平均
この研究の注釈:

50mg of DHEA over 6 months in menopausal women showed that testosterone and estrogen increased, while SHBG decreased only in overweight women significantly. Plasma levels of neurosteroids (beta-endorphin and allopregnanolone) increased while cortisol and gonadotropins decreased.

SHBG decreased only in the subset of postmenopausal women who were older and overweight.


Supplementation With DHEA: Effect On Muscle Size, Strength, Quality Of Life, And Lipids
効果 なし
試験方法 二重盲検法
試験期間 1-6 ヶ月
被験者数 50
性別 女性
年齢 45-64, 65+
この研究の注釈:

DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.


管理人 :慶應義塾大学の理工学部卒業後、国内外でコンサルティング業務やスタートアップの立ち上げを経験した後、日本に帰国してから健康・医療の情報を収集して発信しています。 趣味:ネットサーフィン、読書(最近かなり減ってますが)、アウトドア(家族と) 毎日メディテーションとジョギング、筋トレ・ストレッチしています。既婚で子供4人(男女女男)です。