conjugated-linoleic-acid-c-reactive-protein

この研究の注釈：

4.2g of CLA daily for 3 months was able to raise C-Reactive Protein levels without influencing TNF-a levels or cellular adhesion factors.

この研究の注釈：

In postmenopausal, diabetic women; CLA at 8g daily for 16 weeks was unable to influence parameters of glucose metabolism (almost reaching significance in decreasing glucose) whereas the control, safflower oil, was able to decrease HbA1c levels.

16 weeks of safflower oil was able to slightly benefit lipid metabolism, and nothing was reported with CLA.

この研究の注釈：

In obese but otherwise healthy persons, CLA for 12 weeks at 6.4g was able to increase lean mass by 0.64kg (3.2g CLA uneffective); this was accompanied by increased markers of inflammation (IL-6, C-RP). Fat showed a trend to decline, but was insignificant.

More side-effects reported in 6.4g CLA group, mostly gastrointestinal in nature.

この研究の注釈：

4g of CLA daily in overweight adults aged 40-70 years (2.5g c9t11, 0.6g t10c12) over 6 months

Weight was not significantly differnet between groups, although a trend for weight gain attenuation was noted (0.21 ± 0.22 kg gain in CLA, 0.65 ± 0.16kg gain in placebo; P = 0.11)

この研究の注釈：

6g of supplementation (77% CLA by weight; 1:1 ratio of the two main isomers) for 12 weeks noted significant improvements in quality of life () associated with supplementation (pilot study, no placebo group). The benefit seen according to CDAI rating was 13.1% at week 6 and 23.6% at 12 weeks with the authors suggesting that it may not be clinically significant.

Secretion of IL-2 increased from isolated CD4+ and CD8+ lymphocytes, while serum IL-6 was higher after 12 weeks. IL-8, IL-1β, IL-10, TNF-α, or IL-12p70 were all unaffected, and lymphocyte secretion of TNF-α and IFNy was reduced.

この研究の注釈：

Three groups were done in overweight and unhealthy adults; milk with naturally occurring c9t11 CLA, milk with the same (1.3g/day) content of mixed isomer CLA, and milk with 0.2g CLA (CLA depleted). Each trial period was 8 weeks, with a 4 week washout, and each subject was randomized to each trial period.

No difference was noted in triglycerides or cholesterol levels between treatment periods, nor were liver enzymes altered.

この研究の注釈：

Glucose was significantly increased by 6.3% and insulin sensitivity (assessed by HOMA) decreased after type II diabetic patients consumed 3g CLA daily for 8 weeks. No effects on CRP or IL-6, and HDL-C increased by 8%.

この研究の注釈：

Relative to safflower oil as a control at 3.5g daily, two experimental groups were used. 3.5g of oil comprising 2.7g of 50/50 CLA isomers, and 3.5g oil comprising 2.7g of jsut the c9t11 isomer. Population was overweight and hyperlipidemic men, and no dietary controls were in place (free-living conditions) over 56 days.

No differences existed in lean mass, fat mass, or weight; nor were any trends noted. A decrease in circulating TNF-a was noted with both CLA treatments, and all other parameters came back statistically insignificant.