conjugated-linoleic-acid-triglycerides

この研究の注釈：

6g of CLA daily for 6 months in obese humans did not significantly reduce fat mass relative to placebo.

AST levels were significantly lower with CLA than placebo (sunflower oil), triglycerides increased at 52 weeks to 150.5mg/dL from 118.2mg/dL (control)

この研究の注釈：

CLA mix (41% c9t11, 40% t10c12) was compared against CLA Milk (85% c9t11, 7% t10c12) and oleic acid as control in 75 postmenopausal women; all at 5.5g for 16 weeks. No reported differences were noted in body weight or fat mass, but a significant relative drop in HDL cholesterol (-0.2mmol/L) relative to oleic acid was seen, and an increase (0.16mmol/L) of triglycerides was noted.

No effect on IL-6, ICAM-1, or VCAM-1 was noted. CRP was higher in the CLA mixture group relative to the CLA milk group, whereas both groups had a higher 8-iso PGF2α level relative to oleic acid (60% CLA mix, 25% CLA milk)

CLA milk group reported a lower energy intake during the study period, 87% of the CLA mix group.

この研究の注釈：

A randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or placebo while performing an 8-week protocol of aerobic exercise. While all participants showed increases in oxygen uptake and decreases in body fat, there was no statistical difference in the CLA group compared to placebo. Thus, 8 weeks CLA supplementation when combined with aerobic exercise did not increase fat loss in obese women.

この研究の注釈：

In females divided to either CLA (3.6g), exercise, or a combination thereof (with a fourth control group) for 6 weeks, it was shown that the effects of CLA and exercise on body composition are independent and thus additive; no synergism noted.

この研究の注釈：

2.2g of CLA daily for 3 weeks (1g of both main isomers) in healthy Japanese adults was able to increase TGs to about 112% of baseline levels, without significantly influencing lipoprotein metabolism or liver enzymes.

この研究の注釈：

Three groups were done in overweight and unhealthy adults; milk with naturally occurring c9t11 CLA, milk with the same (1.3g/day) content of mixed isomer CLA, and milk with 0.2g CLA (CLA depleted). Each trial period was 8 weeks, with a 4 week washout, and each subject was randomized to each trial period.

No difference was noted in triglycerides or cholesterol levels between treatment periods, nor were liver enzymes altered.

この研究の注釈：

Butter, at 115g per day, was compared against butter (incorporated into foods). One was enriched with 5.5g CLA (39.4% c9t11, 38.5% t10c12) and the other had insignificant CLA levels, instead having lesser fatty acids and the subjects having to seek out additional fatty acids daily. Dietitian intervention had minimized differences, but some existed between group (CLA group reporting slightly higher caloric and PUFA intake)

Urine 8-iso-PGF2α increased to 183% of the control group after CLA ingestion, an in vivo marker of lipid peroxidation. No other changes were noted.

この研究の注釈：

Persons aged 35-65 with at least 2 criteria for metabolic syndrome ingested 3g of CLA via 500mL milk, relative to placebo of CLA-free milk, for 12 weeks.

Fat mass only significantly decreased when BMI was controlled for the obese class, and no changes observed in the placebo group.