Creatine Supplementation In Parkinson Disease: A Placebo-controlled Randomized Pilot Trial


2 year trial of creatine monohydrate supplementation on Parkinson’s Disease.

Improvements in mood noted, but no improvements on parameters of Parkinson’s disease (as measured by the Unified Parkinson’s Disease Rating Scale)

Effect Of Creatine Monohydrate On Clinical Progression In Patients With Parkinson Disease: A Randomized Clinical Trial


Participants with early-stage Parkinson’s disease (within 5 years of diagnosis) who also underwent dopaminergic therapy were randomized to receive a placebo or 5 g of creatine twice a day (10 g/day) for a minimum of 5 years. At a preplanned checkpoint, however, the trial was terminated early for futility, as no difference in clinical function (using 5 different scales) was observed between the placebo and creatine groups.