inositol-treatment-of-pcos

この研究の注釈：

In women with PCOS, supplementation of 2,000mg _myo_-inositol was able to improve oocyte maturation and quality.

この研究の注釈：

Supplementation of myo-inositol by itself at 2g daily for a period of six months in women with PCOS was associated with improvements in diastolic blood pressure. The combination with D-chiroinositol was the same at a lower dose (550mg and 13.8mg, respectively) when measured at six months, but seemed to act faster as inositol at 2g required six months to be fully effective.

この研究の注釈：

200mg of inositol daily (in two divided doses of 100mg) for a period of 12 weeks in women with PCOS was ineffective in improving the glucose metabolic markers yet was effective in reducing body weight and improving fertility.

この研究の注釈：

6-8 weeks of supplementation with 600mg D-chiro-inositol daily in women with PCOS who also had an average BMI was able to increase ovulation secondary to reducing androgens, and appears to be effective in improving other biomarkers of health such as blood pressure and triglycerides.

この研究の注釈：

Supplementation of inositol in young women with PCOS (of which hirstuism and acne are common side effects) was therapeutic over the course of six months of treatment at 2,000mg.

Acne at baseline was either moderate (68%) or severe (32%) and, after supplementation, it was reduced respectively to 34% and 13% with more than half the sample (53%) noting an abolishment of all acne.

No placebo control group was used.

この研究の注釈：

Supplementation of 4,000mg inositol daily for a period of 12-16 weeks in women with PCOS was able to improve tolerance to glucose and glucose handling (as well as reduce the amount of insulin secreted in response to a meal) with minor benefits to cardiovascular health as well.

この研究の注釈：

2,000mg inositol daily in overweight women with PCOS

この研究の注釈：

Supplementation of 1,200mg Myo-inositol daily for a period of 12 weeks in normal weight women (22-30yrs) with PCOS was able to decrease weight (−1.83+/-1.86kg, very unreliable in magnitude) and improved markers of glucose and androgen metabolism. An improvement in oxidative biomarkers was also noted (GSH in red blood cells).

この研究の注釈：

A three month pretreatment of inositol supplementation in women with PCOS subject to undergo fertilization therapy noted that inositol at 2,000mg (400mcg folic acid also used as placebo) was more effective than placebo in improving fertilization rates and fertility.

この研究の注釈：

Three months supplementation of inositol at 2g daily in women with PCOS who then subsequently underwent ovarian induction noted that supplementation was associated with improved fertility.

この研究の注釈：

Supplementation of _myo_-inositol at 4g daily in women with PCOS undergoing ovulation induction for the purpose of intracytoplasmic sperm injections noted that supplementation resulted in improve oocyte maturation and reduced requirements of hormones needed to induce ovulation (rFSH). Pregnancy rates were not affected.

この研究の注釈：

Supplementation of inositol at 2,000mg daily for an average of 35 days was associated with improved fertility and period regulatory over the course of the next six months.

この研究の注釈：

Supplementation of inositol at 4g daily (initially without FSH treatment, but it was introduced in both groups if no pregnancy occurred) was more effective than 1,500mg metformin in improving fertility rates in women with PCOS.

この研究の注釈：

4g of inositol daily for a period of 16 weeks in women with PCOS was ineffective in improving parameters of insulin sensitivity while it was sufficient to improve biomarkers of steroid metabolism and fertility. Weight was decreased in all subjects who were not morbidly obese.