Long-term Effect Of Betaine On Risk Factors Associated With The Metabolic Syndrome In Healthy Subjects


In otherwise healthy adults given betaine supplementation at 4g daily for a period of six months, there was no significant influence on organ function biomarkers (kidney and liver) nor any significant influence on lipid profiles. Homocysteine was actually not significantly affected, as the 12% difference between groups (increase in placebo, stasis in supplementation) faile to reach statistical significance.

An increase was noted in apolipoprotein A1 and PAI-1.