dehydroepiandrosterone-igf-1

この研究の注釈：

25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.

この研究の注釈：

50mg of DHEA over 12 weeks in healthy postmenopausal women with an average age of 64.6yrs and who were sedentary at the start of the study.

With the introduction of exercise, beneficial changes in body composition were due to exercise and there was no difference in the DHEA group relative to placebo.

A reduction in small dense LDL particles (oxidized LDL usually) was noted.

研究の資金源に関する問題点：

NIH grant, likely a nonissue

この研究の注釈：

DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)

この研究の注釈：

*Confounded with low dose [Vitamin D] and high-dose calcium [Calcium], although placebo group took those supplements as well and thus it is unlikely to influence final results*

Over 2 years of supplementation at 50mg daily in older individuals, testosterone estrogen and IGF-1 increase in groups consuming DHEA.

Bone mineral density increased in women, but not men.

この研究の注釈：

2 months of DHEA supplements, 50mg at bedtime, was able to increase circulating levels of Platelet cyclic guanosine-monophosphate, a biomarker for Nitric Oxide.

It increased testosterone and estrogen, as well as plasminogen activating factor-1. Interestingly, DHEA also lowered LDL. Other biomarkers measured were not significantly affected.

この研究の注釈：

DHEA at 50mg for 4 months was unable to influence serum testosterone levels in men, while it increased testosterone levels only in women with low circulating androgens. SHBG dropped in men and women, and DHEA-S in serum increased in both groups.

No effects on carbohydate metabolism or insulin sensitivity were seen. Fat mass decreased, no effects on well being and quality of life were seen.

Patients were hypoadrenics.